Article
Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing.
Nature methods - 1 Jul 2016
Quispe-Tintaya Wilber, Gorbacheva Tatyana, Lee Moonsook, Makhortov Sergei, Popov Vasily N, Vijg Jan, Maslov Alexander Y
Abstract excerpt
The detection and quantification of low-abundance somatic DNA mutations by high-throughput sequencing is challenging because of the difficulty of distinguishing errors from true mutations. There are several approaches available for analyzing somatic point mutations and small insertions or deletions, but an accurate genome-wide assessment of somatic structural variants (somSVs) in bulk DNA is still not possible....
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