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Article

CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.

Circulation research - 19 Jan 2024

Lv Jian-Jun, Wang Hao, Zhang Cong, Zhang Tian-Jiao, Wei Hao-Lin, Liu Ze-Kun, Ma Yi-Hui, Yang Zhi, He Qian, Wang Li-Juan, Duan Li-Li, Chen Zhi-Nan, Bian Huijie

Abstract excerpt

BACKGROUND: Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions is determined by macrophages. This study aimed to investigate the specific role of myeloid-derived CD147 (cluster of differentiation 147) in atherosclerosis and its translational significance. METHODS AND RESULTS: We generated mice with a myeloid-specific...

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PMID: 38166463
DOI: 10.1161/CIRCRESAHA.123.323223

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