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Article

Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice.

Atherosclerosis - 1 Nov 2017

Zhao Liyang, Cozzo Alyssa J, Johnson Amy R, Christensen Taylor, Freemerman Alex J, Bear James E, Rotty Jeremy D, Bennett Brian J, Makowski Liza

Abstract excerpt

BACKGROUND AND AIMS: Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids, although overlap exists. We previously demonstrated that MΦ fatty acid transport protein 1 (FATP1, Slc27a1) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29035781
DOI: 10.1016/j.atherosclerosis.2017.10.009
PMCID: PMC5705203

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