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Article

The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype.

International journal of molecular sciences - 9 Sept 2021

Kiepura Anna, Stachyra Kamila, Wiśniewska Anna, Kuś Katarzyna, Czepiel Klaudia, Suski Maciej, Ulatowska-Białas Magdalena, Surmiak Marcin, Olszanecki Rafał

Abstract excerpt

Background: Over the past few years, a better understanding of the biology of G-protein coupled receptors (GPRs) has led to the identification of several receptors as novel targets for free fatty acids (FFAs). FFAR4 has received special attention in the context of chronic inflammatory diseases, including atherosclerosis, obesity and NAFLD, through to its anti-inflammatory effect. Methods: The present study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34575934
DOI: 10.3390/ijms22189772
PMCID: PMC8471331

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