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Article

From brain imaging phenotypes to vascular dementia subtypes: A comprehensive mendelian randomization study.

Archives of gerontology and geriatrics - 1 Mar 2026

Chen Congai, Zhang Zehan, Liu Qinglin, Zhou Pinyi, Deng Yiwen, Mao Jingwei, Liu Lu, Li Bin

Abstract excerpt

BACKGROUND: Vascular dementia (VaD) is a heterogeneous disorder with distinct subtypes, each exhibiting unique neuropathological profiles. Although neuroimaging studies have identified some subtype-specific structural brain alterations, a systematic investigation establishing causal relationships between imaging-derived phenotypes (IDPs) and the development of specific VaD subtypes remains absent from current...

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Topics

Humans
Dementia, Vascular
Mendelian Randomization Analysis
Phenotype
Brain
Neuroimaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Male

Magnetic Resonance Imaging

Female

Bayes Theorem

Gray Matter

Source

Identifiers

PMID: 41420912
DOI: 10.1016/j.archger.2025.106116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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