Article

A foundation model for mapping the phenomic and genetic landscape of cerebral small vessel disease biomarkers

2025-12-27

Abstract excerpt

Cerebral small vessel disease (CSVD) is a leading cause of age-related cognitive decline and neurological disorders, yet its precise characterization in large populations has been constrained by reliance on subjective neuroimaging ratings. To address this, we developed CSVDtransformer, a foundation model that simultaneously quantifies six key CSVD biomarkers from structural brain MRI. In 3,718 subjects, the model...

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Literature Corpus work: b620df53-a76f-5b82-aa53-6b48ee8302ab
DOI: 10.64898/2025.12.19.25342615

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