Causal Relationship Between Ischemic Stroke and Vascular Dementia: A Mendelian Randomization Study.

Abstract excerpt

Ischemic stroke (IS) is a major cause of disability and mortality worldwide, and vascular dementia (VaD) is a common dementia subtype associated with cerebrovascular injury. Observational studies have suggested a relationship between IS and VaD, but these studies are vulnerable to confounding and reverse causality. This protocol describes a reproducible two-sample Mendelian randomization (MR) workflow for...

Topics

• Humans
• Ischemic Stroke
• Dementia, Vascular
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide