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Exploring the bidirectional relationships between alzheimer's disease and cerebral small vessel disease: Insights from mendelian randomization

8 Feb 2025

Abstract excerpt

OBJECTIVE: This study aimed to elucidate the bidirectional causal relationships between Alzheimer's disease (AD), cerebral small vessel disease (CSVD), and the effect of inflammatory cytokines on AD and CSVD using Mendelian randomization (MR). METHOD: We employed publicly available summary-level data from genome-wide association studies for AD, CSVD, and 91 inflammatory cytokines. Genetic variants strongly...

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PMID: 39929297
DOI: 10.1016/j.jstrokecerebrovasdis.2025.108259

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