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Article

Impact of the changes in substrate specificity of herpes simplex virus 1 protein kinase Us3 on viral infection in vitro and in vivo.

Journal of virology - 22 Jul 2025

Shio Saori, Kato Akihisa, Kawasaki Jurika, Takeshima Kousuke, Maruzuru Yuhei, Koyanagi Naoto, Harima Hayato, Kawaguchi Yasushi

Abstract excerpt

A serine-threonine protein kinase (PK), Us3, encoded by herpes simplex virus 1 (HSV-1), shares substrate specificity with host cellular PKs, protein kinase A (PKA), and AKT. Many Us3 substrates have been identified, and it is thought that during HSV-1 infection, Us3 fine-tunes the phosphorylation levels of individual substrates within their repertoire. However, the significance of this regulatory fine-tuning by...

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Identifiers

PMID: 40586577
DOI: 10.1128/jvi.00400-25
PMCID: PMC12282182

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