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Article

Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.

Journal of virology - 1 Oct 2010

Walters Matthew S, Kinchington Paul R, Banfield Bruce W, Silverstein Saul

Abstract excerpt

A serine/threonine (S/T) kinase encoded by the US3 gene of herpes simplex virus type 1 (HSV-1) is conserved in varicella-zoster virus (VZV) and pseudorabies virus (PRV). Expression of US3 kinase in cells transformed with US3 expression plasmids or infected with each virus results in hyperphosphorylation of histone deacetylase 2 (HDAC2). Mapping studies revealed that each US3 kinase phosphorylates HDAC2 at the...

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Identifiers

PMID: 20660201
DOI: 10.1128/JVI.00981-10
PMCID: PMC2937806

Genes

HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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