Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis.

doi:10.1128/JVI.00446-16

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Article

Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis.

Journal of virology - 15 Jun 2016

Kato Akihisa, Ando Tomoko, Oda Shinya, Watanabe Mizuki, Koyanagi Naoto, Arii Jun, Kawaguchi Yasushi

Abstract excerpt

UNLABELLED: The herpes simplex virus 1 (HSV-1) Us8A gene overlaps the gene that encodes glycoprotein E (gE). Previous studies have investigated the roles of Us8A in HSV-1 infection using null mutations in Us8A and gE; therefore, the role of Us8A remains to be elucidated. In this study, we investigated the function of Us8A and its phosphorylation at serine 61 (Ser-61), which we recently identified as a...

Topics

Animals
Cell Line
Chlorocebus aethiops
Female
Herpes Simplex
Herpesvirus 1, Human
Keratitis, Herpetic
Mice
Mice, Inbred ICR
Mutation
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Serine-Threonine Kinases

Trigeminal Ganglion

Vero Cells

Viral Proteins

Virulence Factors

Virus Replication

Source

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Identifiers

PMID: 27030266
DOI: 10.1128/JVI.00446-16
PMCID: PMC4886770

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