Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.

doi:10.1128/JVI.03300-13

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Article

Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.

Journal of virology - 1 Mar 2014

Kato Akihisa, Shindo Keiko, Maruzuru Yuhei, Kawaguchi Yasushi

Abstract excerpt

UNLABELLED: Herpes simplex virus 1 (HSV-1) encodes Us3 protein kinase, which is critical for viral pathogenicity in both mouse peripheral sites (e.g., eyes and vaginas) and in the central nervous systems (CNS) of mice after intracranial and peripheral inoculations, respectively. Whereas some Us3 substrates involved in Us3 pathogenicity in peripheral sites have been reported, those involved in Us3 pathogenicity in...

Topics

Animals
Cell Line
Central Nervous System
Chlorocebus aethiops
Enzyme Activation
Female
Genome, Viral
Herpes Simplex
Herpesvirus 1, Human
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphorylation

Protein Serine-Threonine Kinases

Pyrophosphatases

Rabbits

Vero Cells

Viral Proteins

Source

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Identifiers

PMID: 24352467
DOI: 10.1128/JVI.03300-13
PMCID: PMC3958095

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