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Article

MDV-encoded protein kinase US3 phosphorylates WTAP to inhibit transcriptomic m6A modification and cellular protein translation

4 Dec 2024

Abstract excerpt

Marek’s disease virus (MDV)-encoded U S 3 is a highly conserved serine/threonine protein kinase in alpha-herpesviruses. In other alpha-herpesviruses, such as pseudorabies virus (PRV), U S 3 phosphorylates the N6-methyladenosine (m 6 A) methyltransferase Wilms tumor 1-associated protein (WTAP), inhibiting m 6 A modification. However, the role and mechanism of U S 3-mediated WTAP phosphorylation during MDV...

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Cardiac Structural Anomalies and Repair
RNA modifications and cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39644648
DOI: 10.1016/j.vetmic.2024.110335

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