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Article

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1.

Nature cell biology - 1 Aug 2001

Farassati F, Yang A D, Lee P W

Abstract excerpt

The importance of herpes simplex viruses (HSV) as human pathogens and the emerging prospect of using mutant derivatives of HSV-1 as potential anti-cancer therapeutics have necessitated a thorough investigation into the molecular basis of host-cell permissiveness to HSV. Here we show that NIH-3T3 cells transformed with the oncogenes v-erbB, activated sos or activated ras become significantly more permissive to...

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PMID: 11483960
DOI: 10.1038/35087061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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