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Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride.

Archives of toxicology - 1 Aug 2023

Dodge Annette E, LeBlanc Danielle P M, Zhou Gu, Williams Andrew, Meier Matthew J, Van Phu, Lo Fang Yin, Valentine Iii Charles C, Salk Jesse J, Yauk Carole L, Marchetti Francesco

Abstract excerpt

Mutagenicity testing is an essential component of health safety assessment. Duplex Sequencing (DS), an emerging high-accuracy DNA sequencing technology, may provide substantial advantages over conventional mutagenicity assays. DS could be used to eliminate reliance on standalone reporter assays and provide mechanistic information alongside mutation frequency (MF) data. However, the performance of DS must be...

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Identifiers

PMID: 37341741
DOI: 10.1007/s00204-023-03527-y
PMCID: PMC10322784

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