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Power analyses to inform Duplex Sequencing study designs for MutaMouse liver and bone marrow.

Environmental and molecular mutagenesis - 1 Oct 2024

Esina Elena, Dodge Annette E, Williams Andrew, Schuster David M, LeBlanc Danielle P M, Marchetti Francesco, Yauk Carole L

Abstract excerpt

Regulatory genetic toxicology testing is essential for identifying potentially mutagenic hazards. Duplex Sequencing (DS) is an error-corrected next-generation sequencing technology that provides substantial advantages for mutation analysis over conventional mutagenicity assays including: improved accuracy of mutation detection, ability to measure changes in mutation spectrum, and applicability across diverse...

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PMID: 39267335
DOI: 10.1002/em.22619

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