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Mutational analysis of the Drosophila CMG helicase reveals relationships among chromosome integrity and the maintenance of spindle and centrosome structure.

Genetics - 3 Sept 2025

Graziadio Lucia, Scatolini Livia, Bucciarelli Elisabetta, Raffa Grazia Daniela, Bonaccorsi Silvia, Gatti Maurizio

Abstract excerpt

The CMG (Cdc45-MCM-GINS) complex is a conserved helicase that plays an essential DNA unwinding function at replication forks. Here, we analyzed the mitotic phenotypes caused in Drosophila by knockdown of Cdc45, Mcm5, and the four GINS genes (Sld5, Psf1, Psf2, and Psf3). Silencing of these genes resulted in virtually identical mitotic phenotypes. Brain cells from mutant and RNAi larvae showed severe defects in...

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PMID: 40577589
DOI: 10.1093/genetics/iyaf124

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