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Article

Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity.

Cell - 4 Apr 2003

Takada Saeko, Kelkar Anju, Theurkauf William E

Abstract excerpt

In syncytial Drosophila embryos, damaged or incompletely replicated DNA triggers centrosome disruption in mitosis, leading to defects in spindle assembly and anaphase chromosome segregation. The damaged nuclei drop from the cortex and are not incorporated into the cells that form the embryo proper. A null mutation in the Drosophila checkpoint kinase 2 tumor suppressor homolog (DmChk2) blocks this mitotic response...

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Identifiers

PMID: 12679037
DOI: 10.1016/s0092-8674(03)00202-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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