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Article

Human Genetic Evidence Does Not Support a Causal Role for Reduced FXI Levels in Heart Failure Pathogenesis-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2025

Daghlas Iyas, Gill Dipender

Abstract excerpt

BACKGROUND: Coagulation factor XI (FXI) is a promising therapeutic target for preventing thromboembolic disease while preserving hemostasis. However, recent translational and epidemiological findings have raised concerns that lowering FXI levels may increase heart failure risk. To clarify these potential risks, we investigated whether lifelong genetically reduced FXI levels were associated with risk of heart...

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Identifiers

PMID: 40567226
DOI: 10.1161/ATVBAHA.125.322971

Genes

F11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Human Genetic Evidence Does Not Support a Causal Role for Reduced FXI Levels in Heart Failure Pathogenesis-Brief Report.PMID 40567226Read ↗

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