Article
Fibrinogen plasma levels modify the association between the factor XIII Val34Leu variant and risk of coronary artery disease: the EPIC-Norfolk prospective population study.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2006
Boekholdt S M, Sandhu M S, Wareham N J, Luben R, Reitsma P H, Khaw K-T
Abstract excerpt
BACKGROUND: The factor (F) XIII Val34Leu variant has been implicated in coronary artery disease (CAD). In vitro evidence suggests an interaction between this variant and fibrinogen concentrations in determining thrombus structure. OBJECTIVES: To test whether this interaction is relevant in influencing coronary risk in apparently healthy individuals. METHODS: In an 8-year prospective population study of 25 663 men...
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