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Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke Prevention

6 Apr 2025

Abstract excerpt

BACKGROUND: While interindividual variations in concentration and function of coagulation cascade proteins are established risk factors for venous thromboembolism (VTE), their associations with arterial ischemic stroke are less well defined. METHODS: We identified and validated genetic proxies for lifelong, randomized perturbations of coagulation cascade proteins in genome-wide association studies of circulating...

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PMID: 40188416
DOI: 10.1161/strokeaha.124.049808

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