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Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

17 Jun 2025

Abstract excerpt

Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that account for their biological differences. Here we show using single cell analysis that HVs harbor a tumor cell state characterized by expression of MUC16 (CA125), MUC4, and KRT24....

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40527915
DOI: 10.1038/s41467-025-59888-8

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