Article
Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight.
Cell reports. Medicine - 21 Dec 2021
Hurst Carolyn D, Cheng Guo, Platt Fiona M, Castro Mauro A A, Marzouka Nour-Al-Dain S, Eriksson Pontus, Black Emma V I, Alder Olivia, Lawson Andrew R J, Lindskrog Sia V, Burns Julie E, Jain Sunjay, Roulson Jo-An, Brown Joanne C, Koster Jan, Robertson A Gordon, Martincorena Inigo, Dyrskjøt Lars, Höglund Mattias, Knowles Margaret A
Abstract excerpt
Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that show...
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