Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes

Abstract excerpt

Histological and molecular analyses of urothelial carcinoma often reveal intratumoural and intertumoural heterogeneity at the genomic, transcriptional and cellular levels. Despite the clonal initiation of the tumour, progression and metastasis often arise from subclones that can develop naturally or during therapy, resulting in molecular alterations with a heterogeneous distribution. Variant histologies in tumour...

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• Share to Bladder and Urothelial Cancer Treatments
• Share to Epigenetics and DNA Methylation
• Share to Urinary and Genital Oncology Studies