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Single-cell RNA sequencing reveals the cellular and molecular characteristics of high-grade and metastatic bladder cancer

11 May 2023

Abstract excerpt

PURPOSE: Metastatic bladder cancer (BC) has the highest somatic mutation frequency and recurrence rate of all tumors. However, the cellular and molecular characteristics of BC remain unclear. METHODS: We performed single-cell RNA sequencing (scRNA-seq) on the samples of paracancerous normal tissue (PNT), primary tumor (PT) and lymph node metastasis (LNM). The proportions and gene expression profiles of different...

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PMID: 37170046
DOI: 10.1007/s13402-023-00820-x

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