Article

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state

2024-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Histologic variant (HV) subtypes of bladder cancer are clinically aggressive tumors that are more resistant to standard therapy compared to conventional urothelial carcinoma (UC). Little is known about the transcriptional programs that account for the morphological and biological differences in HV tumors. To investigate the tumor biology of HV bladder cancers, we generated a single cell RNA sequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1d221d8-cf3d-5742-b51b-b3fb8a761b57
DOI: 10.1101/2024.05.20.595039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell stateDOI 10.1101/2024.05.20.595039Read

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expressionSemantic proximity Read

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.Semantic proximity Read

Molecular Subtypes of Bladder Cancer.Semantic proximity Read

Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges.Semantic proximity Read

International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4Semantic proximity Read

Integrated analysis of single-cell and bulk RNA sequencing predicts prognosis and therapeutic response using malignant epithelial cells marker genes in bladder cancerSemantic proximity Read

Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current DevelopmentSemantic proximity Read

Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancerSemantic proximity Read

Molecular subtypes of bladder cancer do not display microenvironment- or metastasis-induced plasticitySemantic proximity Read

A multicenter review of histopathology of variants in the context of upper urinary tract urothelial carcinoma and their impact on clinical outcomesSemantic proximity Read

Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder CancerSemantic proximity Read

Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial CarcinomaSemantic proximity Read