Article

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

2021-11-02

Abstract excerpt

Intratumor heterogeneity (ITH) of bladder cancer (BLCA) facilitates therapy resistance and immune evasion to affect clinical prognosis directly. However, the molecular and cellular mechanism generating ITH in BLCA remains elusive. Here we show that a TM4SF1-positive cancer subpopulation (TPCS) drives ITH diversification in BLCA. By extensive profiling of the epigenome and transcriptome of BLCA from 79 donors acros...

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Literature Corpus work: 810c9465-4091-5e74-9bc3-f758169987af
DOI: 10.1101/2021.10.30.466556

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