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Article

Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases

2 Jul 2025

Abstract excerpt

BACKGROUND: Transcriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity (ITH) and plasticity can significantly impact diagnosis and patient management, yet their extent in BC remains highly debated. Here, we investigated whether the three main bladder cancer...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40605119
DOI: 10.1186/s40164-025-00682-z

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