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Article

Properties of Acute Activation and Inhibition of the β3 Homomeric GABAA Receptor Mediated by Protonation of Conserved Histidine Residues.

ACS chemical neuroscience - 2 Jul 2025

Pierce Spencer R, Germann Allison L, Zhou Yu, Menon Saumith L, Gu Xinghan, Lingle Christopher J, Evers Alex S, Steinbach Joe Henry, Akk Gustav

Abstract excerpt

GABAA receptors are inhibitory transmitter-gated ion channels formed of various combinations of the 19 homologous subunits cloned to date. Changes in extracellular pH have been shown to directly activate the receptor or modulate its activity elicited by a chemical agonist, but the direction and magnitude of the effect depend on the subunit composition of the receptor. Here, we investigated the acute effect of...

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Identifiers

PMID: 40521779
DOI: 10.1021/acschemneuro.5c00256
PMCID: PMC12395557

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