Article

Structural basis for activation and potentiation in a human α5β3 GABAA receptor

2025-10-24

Abstract excerpt

<title>Abstract</title> <p>Neuromodulatory drugs, including anesthetics and anticonvulsants, have been shown to mediate inhibitory and excitatory effects through different populations of type-A ɣ-aminobutyric acid receptors (GABAARs) in the central nervous system. GABAARs in the hippocampus containing α5 subunits have been particularly implicated in learning and memory. The α5 subunit is thought to primarily coas...

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Literature Corpus work: 29c30e9b-b25b-5a7f-86bd-5b3587bec285
DOI: 10.21203/rs.3.rs-5975786/v1

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