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Article

Molecular basis for modulation of recombinant alpha1beta2gamma2 GABAA receptors by protons.

Journal of neurophysiology - 1 Aug 2004

Huang Ren-Qi, Chen Zhenglan, Dillon Glenn H

Abstract excerpt

We have previously shown that extracellular protons inhibit recombinant and native GABA(A) receptors. In this report, we studied the site(s) and mechanism by which protons modulate the GABA(A) receptor. Whole cell GABA-activated currents were recorded from human embryonic kidney (HEK) 293 cells expressing recombinant alpha1beta2gamma2 GABA(A) receptors. Protons competitively inhibited the response to GABA and...

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Identifiers

PMID: 15028749
DOI: 10.1152/jn.01040.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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