Article

Structural basis for activation and potentiation in a human α5β3 GABA <sub>A</sub> receptor

2025-01-29

Abstract excerpt

<h4>SUMMARY</h4> General anesthetics like etomidate mediate amnesic as well as sedative effects through different populations of gamma amino butyric acid receptors (GABA A Rs) in the central nervous system. The amnesic effects have largely been attributed to α5-subunit-containing receptors in the hippocampus, indicating a clear role in learning and memory for these receptors. The α5 subunit is thought to primari...

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Literature Corpus work: 18b7f1a8-fd7d-5525-8612-82137a268e25
DOI: 10.1101/2025.01.27.635004

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