Article
Mutant EZH2 alters the epigenetic network and increases epigenetic heterogeneity in B cell lymphoma.
PLoS biology - 1 Jun 2025
Griess Ofir, Furth Noa, Harpaz Nofar, Di Bernardo Nicoletta, Salame Tomer-Meir, Dassa Bareket, Karagiannidis Ioannis, Isshiki Yusuke, Gross Menachem, Melnick Ari M, Béguelin Wendy, Ron Guy, Shema Efrat
Abstract excerpt
Diffuse large B cell lymphomas and follicular lymphomas show recurrent mutations in epigenetic regulators; among these are loss-of-function mutations in KMT2D and gain-of-function mutations in EZH2. To systematically explore the effects of these mutations on the wiring of the epigenetic network, we applied a single-cell approach to probe a wide array of histone modifications. We show that mutant-EZH2 elicits...
Read the complete abstract on PubMedTopics
- Humans
- Male
- Animals
- Mice
- Cell Line, Tumor
- Epigenesis, Genetic