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Article

EZH2 mutations increase the heterogeneity of chromatin states in lymphoma.

PLoS biology - 1 Jun 2025

Holoch Daniel, Margueron Raphaël

Abstract excerpt

A recent study in PLoS Biology used simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell-cell heterogeneity.

Read the complete abstract on PubMed

Topics

Enhancer of Zeste Homolog 2 Protein
Chromatin
Humans
Mutation
Histones
Lymphoma, B-Cell
Lymphoma

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Source

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Identifiers

PMID: 40512686
DOI: 10.1371/journal.pbio.3003211
PMCID: PMC12165352

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