Article
EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition.
Nature communications - 24 Apr 2024
Romero Pierre, Richart Laia, Aflaki Setareh, Petitalot Ambre, Burton Megan, Michaud Audrey, Masliah-Planchon Julien, Kuhnowski Frédérique, Le Cam Samuel, Baliñas-Gavira Carlos, Méaudre Céline, Luscan Armelle, Hamza Abderaouf, Legoix Patricia, Vincent-Salomon Anne, Wassef Michel, Holoch Daniel, Margueron Raphaël
Abstract excerpt
Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood. Here, we model several PRC2 alterations in one isogenic system to reveal their comparative effects. Focusing then on lymphoma-associated EZH2 mutations, we show that...
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