Article

<i>EZH2</i> mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition

2023-01-03

Abstract excerpt

Mutations in chromatin regulators or their histone substrates are widespread in cancer and often play decisive roles in tumorigenesis. These include Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine 27 methyltransferase that shows distinct alterations in each of a range of tumor types. Mechanistically, this tumor-type specificity is poorly understood. Here, we model several of these alterations in a single...

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Literature Corpus work: 611dd58d-ccdb-528e-bdf8-9ca50178bd55
DOI: 10.1101/2023.01.02.522460

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