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Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer

18 Jun 2015

Abstract excerpt

BACKGROUND: Many cancer cells show distorted epigenetic landscapes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors, allowing the discovery of somatic alterations in the epigenetic machinery and the identification of potential cancer drivers among members of epigenetic protein families. METHODS: We integrated mutation, expression, and copy number data from 5943 tumors from 13 cancer types to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26110843
DOI: 10.1186/1471-2164-16-s8-s5

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