Article
Clusters of mutations from transient hypermutability.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005
Drake John W, Bebenek Anna, Kissling Grace E, Peddada Shyamal
Abstract excerpt
Collections of mutants usually contain more mutants bearing multiple mutations than expected from the mutant frequency and a random distribution of mutations. This excess is seen in a variety of organisms and also after DNA synthesis in vitro. The excess is unlikely to originate in mutator mutants but rather from transient hypermutability resulting from a perturbation of one of the many transactions that maintain...
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