Volatility of Mutator Phenotypes at Single Cell Resolution.

Abstract excerpt

Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Historically, the measurement of mutation rates has relied on scoring the occurrence of rare mutations in target genes in large populations of cells. Averaging mutation rates over large cell populations assumes that new mutations arise at a constant rate during each cell division. If the mutation rate is not constant, an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Pair Mismatch
• Share to DNA Mismatch Repair
• Share to DNA Polymerase II