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Article

Mutational landscape of yeast mutator strains.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2014

Serero Alexandre, Jubin Claire, Loeillet Sophie, Legoix-Né Patricia, Nicolas Alain G

Abstract excerpt

The acquisition of mutations is relevant to every aspect of genetics, including cancer and evolution of species on Darwinian selection. Genome variations arise from rare stochastic imperfections of cellular metabolism and deficiencies in maintenance genes. Here, we established the genome-wide spectrum of mutations that accumulate in a WT and in nine Saccharomyces cerevisiae mutator strains deficient for distinct...

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Source

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Identifiers

PMID: 24449905
DOI: 10.1073/pnas.1314423111
PMCID: PMC3918763

Genes

ATM
ATR
CCNB1
FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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