Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles.

Communications biology - 4 Jan 2021

Dowsett Ian T, Sneeden Jessica L, Olson Branden J, McKay-Fleisch Jill, McAuley Emma, Kennedy Scott R, Herr Alan J

Abstract excerpt

Mutations that compromise mismatch repair (MMR) or DNA polymerase ε or δ exonuclease domains produce mutator phenotypes capable of fueling cancer evolution. Here, we investigate how combined defects in these pathways expands genetic heterogeneity in cells of the budding yeast, Saccharomyces cerevisiae, using a single-cell resolution approach that tallies all mutations arising from individual divisions. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase II

Share to Genetic Heterogeneity

Share to Mutation Rate

Share to Saccharomyces cerevisiae

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 33398111
DOI: 10.1038/s42003-020-01544-6
PMCID: PMC7782790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles.PMID 33398111Read ↗

Volatility of Mutator Phenotypes at Single Cell Resolution.Semantic proximity Read ↗

Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational landscape of yeast mutator strains.Semantic proximity Read ↗

Trajectory and uniqueness of mutational signatures in yeast mutators.Semantic proximity Read ↗

Mutator suppression and escape from replication error-induced extinction in yeast.Semantic proximity Read ↗

Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells.Semantic proximity Read ↗

“The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers”Semantic proximity Read ↗

Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics.Semantic proximity Read ↗

A transient mutational burst occurs during yeast colony development.Semantic proximity Read ↗

Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.Semantic proximity Read ↗

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.Semantic proximity Read ↗

Mutator phenotype in cancer: timing and perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.