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Article

Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer risk.

Journal of translational medicine - 18 Feb 2025

Zhou Ning, Xu Yuanyuan, Huang Yumin, Ye Guoxiang, Luo Liang, Song Zuodong

Abstract excerpt

BACKGROUND: Germline mutations in numerous genes, particularly tumor suppressor genes, markedly heighten the risk of various cancers, including lung cancer, which is the leading cause of cancer-related deaths worldwide. Despite extensive research on well-known genes like BRCA1, BRCA2, and mismatch repair genes, many genetic factors contributing to cancer susceptibility remain unidentified. METHODS: This study...

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Identifiers

PMID: 39966892
DOI: 10.1186/s12967-025-06096-z
PMCID: PMC11837408

Genes

ATM
BRCA2
BRCA1
CHEK2
MSH6
MTOR
TP53

Provenance

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