Article
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1.
Nature communications - 5 Jun 2025
Li Yin, Fang Jie, Ding Yuqi, Zhang Xilong, Liu Ying, Qiu Wanting, Xu He, Kang Yunzhe, Chen Jiayu, Gao Yanyan, Zhao Yan G, Yang Peiguo, Wang Bo, Tian Wenmin, Chen Yang, Bi Wenjian, Zhang Peipei
Abstract excerpt
β-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood. Here, we identify a role for WDR45 in stress granule (SG) disassembly, mediated through its phase separation with Caprin-1. We demonstrate that WDR45 forms gel-like condensates via its WD5 domain, which competitively...
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