Article
Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly.
Science advances - 31 Mar 2023
Kassouf Toufic, Shrivastava Rohit, Meszka Igor, Bailly Aymeric, Polanowska Jolanta, Trauchessec Helene, Mandrioli Jessica, Carra Serena, Xirodimas Dimitris P
Abstract excerpt
The elimination of aberrant inclusions is regarded as a therapeutic approach in neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found within cytoplasmic condensates called stress granules (SGs) are linked to the formation of pathological SGs, aberrant protein inclusions, and neuronal toxicity. We found that inhibition of NEDP1, the enzyme that processes/deconjugates the...
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