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Article

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

Science (New York, N.Y.) - 25 Jun 2021

Gwon Youngdae, Maxwell Brian A, Kolaitis Regina-Maria, Zhang Peipei, Kim Hong Joo, Taylor J Paul

Abstract excerpt

Stress granules are dynamic, reversible condensates composed of RNA and protein that assemble in eukaryotic cells in response to a variety of stressors and are normally disassembled after stress is removed. The composition and assembly of stress granules is well understood, but little is known about the mechanisms that govern disassembly. Impaired disassembly has been implicated in some diseases including...

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Identifiers

PMID: 34739333
DOI: 10.1126/science.abf6548
PMCID: PMC8574224

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