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Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?

8 Jun 2021

Abstract excerpt

Stress granules (SGs) are membraneless cell compartments formed in response to different stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other proteins coalesce together. SGs assembly is crucial for cell survival, since SGs are implicated in the regulation of translation, mRNA storage and stabilization and cell signalling, during stress. One defining feature of SGs is their...

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PMID: 34103467
DOI: 10.1038/s41419-021-03873-8

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