Article
Sequence and parent-of-origin dependent m6A contribute to allele-specific gene expression.
The EMBO journal - 1 Jul 2025
Zhang Ying, Zhang Ze-Yu, Chen Hong-Xuan, Liu Chao, Liu Biao-Di, Lan Ye-Lin, Xie Ying-Yuan, Chen Tao, Chen Shaobo, Feng Guihai, Zhang Zhang, Li Wei, Cao Nan, Wang Xiu-Jie, Luo Guan-Zheng
Abstract excerpt
Multiple regulatory layers influence allele-specific expression (ASE), particularly through sequence-dependent and parent-of-origin-dependent mechanisms at the transcriptional level. However, little is known about ASE regulation at the post-transcriptional level. The most prevalent post-transcriptional mRNA modification, N6-methyladenosine (m6A), plays important roles in regulating gene expression. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.