Article
Allele-specific RNA N 6-methyladenosine modifications reveal functional genetic variants in human tissues.
Genome research - 1 Aug 2023
Cao Shuo, Zhu Haoran, Cui Jinru, Liu Sun, Li Yuhe, Shi Junfang, Mo Junyuan, Wang Zihan, Wang Hailan, Hu Jiaxin, Chen Lizhi, Li Yuan, Xia Laixin, Xiao Shan
Abstract excerpt
An intricate network of cis- and trans-elements acts on RNA N 6-methyladenosine (m6A), which in turn may affect gene expression and, ultimately, human health. A complete understanding of this network requires new approaches to accurately measure the subtle m6A differences arising from genetic variants, many of which have been associated with common diseases. To address this gap, we developed a method to...
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