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M6Allele: a toolkit for detection of allele-specific RNA N6-methyladenosine modifications.

GigaScience - 6 Jan 2025

Zhang Yin, Tang Lin, Zhi Shengyao, Hu Bosu, Zuo Zhixiang, Ren Jian, Xie Yubin, Luo Xiaotong

Abstract excerpt

BACKGROUND: Allelic gene-specific regulatory events are crucial mechanisms in organisms, pivotal to many fundamental biological processes such as embryonic development and chromosome inactivation. Allelic gene imbalance manifests at both RNA expression and epigenetic levels. Recent research has unveiled allelic-specific regulation of RNA N6-methyladenosine (m6A), emphasizing the need for its precise...

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PMID: 40388309
DOI: 10.1093/gigascience/giaf040
PMCID: PMC12087454

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