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Article

Long-read RNA sequencing reveals allele-specific N 6-methyladenosine modifications.

Genome research - 14 Apr 2025

Park Dayea, Cenik Can

Abstract excerpt

Long-read sequencing technology enables highly accurate detection of allele-specific RNA expression, providing insights into the effects of genetic variation on splicing and RNA abundance. Furthermore, the ability to directly sequence RNA enables the detection of RNA modifications in tandem with ascertaining the allelic origin of each molecule. Here, we leverage these advantages to determine allele-biased...

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PMID: 39472020
DOI: 10.1101/gr.279270.124
PMCID: PMC12047277

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